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Table 1 Study designs

From: The effect of exercise-based interventions on health-related quality of life and physical function in older patients with cancer receiving medical antineoplastic treatments: a systematic review

Author, year, country Diagnoses Age, years Exclusion criteria Intervention Control group Timing of tests Outcomes
Delivery Type Frequency & duration Intensity
Arrieta et al [30], 2019
France
Various cancers ≥ 70 ECOG PS > 2
Serious psychiatric or cognitive problems
Inability to walk
Palliative care
Home-based, unsupervised Individualized phoned PA advice (on resistance and aerobic exercises) and booklet with exercises Telephone advice: 2X a month for 6 months, and then 1X a month
Exercise: starting at 2X a week → hereafter adjusted to each participant
Duration:
12 months
Adjusted to each participant’s capability Usual care Baseline
3 months
6 months
12 months
18 months
24 months
Physical functiona
PAb
Cognition
Falls
Hospitalizations
Institutionalizations
Mortality
Maréchal et al [31], 2019
Canada
Various cancer ≥ 65 Physically active
(≥ 75 min. Per week)
Surgery planned within 6 months
Uncontrolled hypertension
Use of beta-blockers
Supervised and unsupervised Aerobic exercises and resistance training 3X a week for 12 weeks
Time: Aerobic: 40 min.
RT: NR
4-week progression period: aerobic workout at 70–75% of HRR → maintain
RT: 2–3 sets of 10–15 rep. with 50–65% of maximal exercise load
Active static stretching Baseline
12 weeks
Physical function
Strength
Aerobic fitness
PAb
Balance
Flexibility
SBTb
PC
NRa
Sajid et al [32], 2016
USA
Prostate cancer ≥ 65 Cognitive impairment
Already performing or planning to perform exercise > ×1 weekly
Home-based, unsupervised EXCAP: walking and resistance training
Wii: exercise with Wii-fit
At least 5X a week for 6 weeks
Time: NR
EXCAP: Walking: 60–70% of HRR and 3–5 rating of perceived exertion according to ACSM scale. Instructed to increase daily steps with 5–20% per week and to reach 10,000 steps per day.
RT: low/moderate intensity, instructed to increase to max. 4 sets with 15 rep.
Wii: same intensity as EXCAP
Usual care Baseline
6 weeks
12 weeks
Physical functiona
Strength
Aerobic fitness
PA
BC
Miki et al [33], 2014
Japan
Breast and prostate cancer ≥ 65 ECOG PS > 1
Bone metastases
Received whole brain irradiation
Severe cardio-respiratory disease
Central nervous system paralysis
Supervised Speed-feedback therapy on bicycle ergometersc 1X a week for 4 weeks
Time: 5 min.
Exercise load: 20 watts with maximum rotations of 80 rpm Usual care Baseline
4 weeks
Cognitiona
QoL
Physical function
  1. Abbreviations: ACSM American College of Sports Medicine, BC Body composition, ECOG Eastern Cooperative Oncology Group, HRR Heart rate reserve, min. Minutes, No. Number, NR Not reported, aPrimary outcome, PA Physical activity, PC Physical capacity, PS Performance status, QoL Quality of life, Rep. Repetitions, RT Resistance training, SBT Sedentary behavior time, bSelf-reported
  2. cParticipants were instructed to pedal a bicycle ergometer to match the target speed arbitrarily displayed on a computer screen. A standard path corresponding to the target number of revolutions was displayed on the computer screen (standard number of revolutions), and the participants pedaled the bicycle ergometer while visually tracking and paying attention to following the path
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